Objective To explore the effect of motivational interview intervention based on self-efficacy theory on caregivers of children with enterostomy.Methods According to literature research and previous studies,motivational interview program was formulated,which included designing motivational interview strategy,screening and training for interviewing nurses. Seventy-two caregivers of children with enterostomy were randomly divided into two groups by using digital random table method with 36 cases in the experimental group and 36 cases in the control group. Five motivational interviews were conducted in the experimental group on the basis of routine health education and follow-up during hospitalization and 1,2,3 months after discharge;while the control group only received routine health education and follow-up. Self-efficacy scores,anxiety levels and complications related to stoma were compared between two groups at 1,2,3 month after discharge.Results After 3 months of intervention,self-efficacy scores of caregivers in the experimental group were higher than the control group,and the anxiety level was lower than the control group(P<0.05). The incidence of peristomal dermatitis in the experimental group was significantly lower than the control group(P<0.05).Conclusion Motivational interview intervention can improve self-efficacy level of caregivers of children with enterostomy,reduce their anxiety level,and reduce the incidence of peristomal dermatitis in children with enterostomy.